Since the founding of a mixed voice choir in 1972, the Choir of Clare College has gained an international reputation as one of the world’s leading university choirs. In addition to its primary function of leading services three times a week in the College chapel, the Choir keeps an active schedule recording, broadcasting, and performing. Former directors have included John Rutter and Timothy Brown. Under the direction of Graham Ross, Director of Music since 2010, it has been praised for its consistently ‘thrilling’ and ‘outstanding’ performances worldwide. Recent engagements include performances with the Orchestra of the Age of the Enlightenment, London Philharmonic Orchestra, Britten Sinfonia, Aalborg Symphony Orchestra, Malaysian Philharmonic Orchestra and Orquesta Sinfonia Nacional de Mexico, as well as recitals in Barcelona's Palau de Musica, El Escorial Madrid, Palacio de Bellas Artes Mexico City, St John's Smith Square London, and across the USA and Canada.

In addition to live performances, the Choir has produced an impressive discography of more than forty recordings. Their recordings under Graham Ross on the Harmonia Mundi label have been released to great critical acclaim, earning praise for ‘exceptional singing’ and ‘immaculate performances’, a Le Choix de France Musique and a Diapason d’Oraward, and garnering a Gramophone Award nomination. The Choir’s nine-disc series of Music for the Church Year has received numerous 5 star reviews in the national and international press, with recordings for Advent (2013), Passiontide (2014), Christmas (2014), Ascensiontide and Pentecost (2015), All Saints and All Souls (2015), Easter (2016), Epiphany (2017), Corpus Christi (2017) and Trinity (2018). The Choir’s album Remembrance featured as Classic FM’s Album of the Week, and other acclaimed recent recordings have included the first recording of choral works by Imogen Holst, and Reformation 1517-2017, a special album of music celebrating the quincentenary of the Reformation; STABAT, focussing on the music of Arvo Pärt; and an album of traditional carols offered by twentieth-century composers, arranged around Benjamin Britten's A Ceremony of Carols. The Choir’s latest album is Ice Land: The Eternal Music, a selection of Icelandic music of the last century, released by the Harmonia Mundi label in 2022 and once again featured as Classic FM's Album of the Week. 

The Choir has toured widely, including in the United States of America, Australia, Japan, China, Singapore, Malaysia, Russia, the Middle East, Iceland and mainland Europe. It has collaborated with the OAE in performances of Handel’s Jephtha under the direction of René Jacobs, with the Australian Chamber Orchestra in Beethoven’s Symphony No. 9, with the LPO at the Royal Festival Hall conducted by Sir Mark Elder and Vladimir Jurowski, and with many other ensembles including the Academy of Ancient Music, European Union Baroque Orchestra, Freiburger Barockorchester, Israel Camerata, Aurora Orchestra, the Schubert Ensemble and the Dmitri Ensemble. The Choir performs a wide range of repertoire throughout the year, and has commissioned and premièred works by many composers, including Herbert Howells, John Tavener, John Rutter, Giles Swayne, James Whitbourn, Andrew Carter, Jonathan Dove, Julian Phillips, Tarik O’Regan, Alexander Raskatov, Graham Ross, Brett Dean, Matthew Martin, Nico Muhly, Anna Semple, Emily Hazarati, Joshua Pacey and Toby Hession.